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Cheilitis is a general term, and there are many recognized types and different causes. According to its onset and course, cheilitis can be either acute or chronic. [2] Most cheilitis is caused by exogenous factors such as dryness (chapping) and acute sun exposure. [2] Allergic tests may identify allergens that cause cheilitis. [3]
Angular cheilitis is thought to be a multifactorial disorder of infectious origin, [10] with many local and systemic predisposing factors. [11] The sores in angular cheilitis are often infected with fungi (yeasts), bacteria, or a combination thereof; [8] this may represent a secondary, opportunistic infection by these pathogens.
Actinic cheilitis is cheilitis (lip inflammation) caused by long term sunlight exposure. Essentially it is a burn, [2] and a variant of actinic keratosis which occurs on the lip. [5] It is a premalignant condition, [6] as it can develop into squamous cell carcinoma (a type of mouth cancer).
Plummer–Vinson syndrome (also known as Paterson–Kelly syndrome [1] or Paterson–Brown-Kelly syndrome in the UK [2]) is a rare disease characterized by dysphagia (difficulty swallowing), iron-deficiency anemia, glossitis (inflammation of the tongue), cheilosis (cracking at the corners of the mouth), and esophageal webs (thin membranes in the esophagus that can cause obstruction). [1]
Iron-deficiency anemia is mainly caused by blood loss, such as may occur during menses or gastrointestinal hemorrhage.This often results in a depapilled, atrophic glossitis, giving the tongue a bald and shiny appearance, along with pallor (paleness) of the lips and other mucous membranes a tendency towards recurrent oral ulceration, [6] and cheilosis (swelling of the lips). [7]
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Imerslund–Gräsbeck syndrome is a rare autosomal recessive, familial form of vitamin B12 deficiency caused by malfunction of the "Cubam" receptor located in the terminal ileum. This receptor is composed of two proteins, amnionless (AMN), and cubilin. A defect in either of these protein components can cause this syndrome.
Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1] Areas of the skin exposed to friction and radiation are typically affected first. [1]