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Tryptase is involved with allergenic response and is suspected to act as a mitogen for fibroblast lines. Tryptase may use the morpheein model of allosteric regulation. [10] Mast cell tryptase-6 is involved in Trichinella spiralis infection in mice through linking adaptive and innate immunity. [11]
17229 Ensembl ENSG00000095917 ENSMUSG00000033825 UniProt Q9BZJ3 P21845 RefSeq (mRNA) NM_012217 NM_010781 RefSeq (protein) NP_036349 NP_034911 Location (UCSC) Chr 16: 1.26 – 1.26 Mb Chr 17: 25.59 – 25.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tryptase delta is an enzyme that in humans is encoded by the TPSD1 gene. Tryptases comprise a family of trypsin-like serine ...
17229 Ensembl ENSG00000197253 ENSMUSG00000033825 UniProt P20231 P21845 RefSeq (mRNA) NM_024164 NM_010781 RefSeq (protein) NP_077078 NP_034911 Location (UCSC) Chr 16: 1.23 – 1.23 Mb Chr 17: 25.59 – 25.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tryptase beta-2, also known as tryptase II, is a proteolytic enzyme that in humans is encoded by the TPSB2 gene. Formerly, the ...
Tryptase alpha-1 and tryptase beta-1 are enzymes that in humans are encoded by the same TPSAB1 gene. [ 5 ] [ 6 ] Beta tryptases appear to be the main isoenzymes expressed in mast cells ; whereas in basophils , alpha tryptases predominate.
Total serum tryptase is elevated in mast cell leukemia. Normal total (alpha + beta) serum tryptase is approximately 6 micro g/L (range 0 to 11 micro g/L). Values of several hundred micro g/L are characteristic of mast cell leukemia. [12] Plasma and urinary histamine levels are frequently elevated in mast cell leukemia.
A mast cell (also known as a mastocyte or a labrocyte [1]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin.Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.
Mast cell activation syndrome (MCAS) is a term referring to one of two types of mast cell activation disorder (MCAD); the other type is idiopathic MCAD. [1] MCAS is an immunological condition in which mast cells, a type of white blood cell, inappropriately and excessively release chemical mediators, such as histamine, resulting in a range of chronic symptoms, sometimes including anaphylaxis or ...
Chymases (EC 3.4.21.39, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine proteases found primarily in mast cells, though also present in basophil granulocytes (e.g. alpha chymase mcpt8).