Search results
Results from the WOW.Com Content Network
Omeprazole was a subject of a patent litigation in the U.S. [66] The invention involved application of two different coatings to a drug in pill form to ensure that the omeprazole did not disintegrate before reaching its intended site of action in stomach. Although the solution by means of two coating was obvious, the patent was found valid ...
[55] [57] An interaction between PPIs and the metabolism of the platelet inhibitor clopidogrel is known and this drug is also often used in people with cardiac disease. [ 58 ] [ 59 ] [ 22 ] There are associations with an increased risk of stroke, but this appears to be more likely to occur in people who already have an elevated risk.
Some examples include exercise, [1] sleep improvement, [2] and dietary habits. [3] Non-pharmacological interventions may be intended to prevent or treat (ameliorate or cure) diseases or other health-related conditions, or to improve public health. They can be educational and may involve a variety of lifestyle or environmental changes. [4]
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
A derivative of timoprazole, omeprazole, was discovered in 1979, and was the first of a new class of drug that control acid secretion in the stomach, a proton pump inhibitor (PPI). [11] [12] Addition of 5-methoxy-substitution to the benzimidazole moiety of omeprazole was also made and gave the compound much more stability at neutral pH. [6]
"Omeprazole".Drug Information Portal.U.S. National Library of Medicine. "Amoxicillin".Drug Information Portal.U.S. National Library of Medicine. "Rifabutin".
The NIC provides a four level hierarchy whose first two levels consists of a list of 433 different interventions, each with a definition in general terms, and then the ground-level list of a variable number of specific activities a nurse could perform to complete the intervention.