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In addition, erythropoietin is bound by circulating red blood cells; low circulating numbers lead to a relatively high level of unbound erythropoietin, which stimulates production in the bone marrow. Recent studies have also shown that the peptide hormone hepcidin may play a role in the regulation of hemoglobin production, and thus affect ...
Epoetin beta , sold under the brand name Neorecormon among others, is a synthetic, recombinant [4] form of erythropoietin, a protein that promotes the production of red blood cells. It is an erythropoiesis-stimulating agent (ESA) that is used to treat anemia , commonly associated with chronic kidney failure and cancer chemotherapy .
Erythropoietin is used to treat people with anemia resulting from critical illness. In a randomized controlled trial, [14] erythropoietin was shown to not change the number of blood transfusions required by critically ill patients. A surprising finding in this study was a small mortality reduction in patients receiving erythropoietin.
The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. [5] EpoR is a 52 kDa peptide with a single carbohydrate chain resulting in an approximately 56–57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as dimers.
The human population exploits and depends on many animal and plant species for food, mainly through agriculture, but also by exploiting wild populations, notably of marine fish. [10] [11] [12] Livestock animals are raised for meat across the world; they include (2011) around 1.4 billion cattle, 1.2 billion sheep and 1 billion domestic pigs. [12 ...
Food is a basic necessity of life, and humans typically seek food out as an instinctual response to hunger; however, not all things that are edible constitute as human food. Display of various foods. Humans eat various substances for energy, enjoyment and nutritional support. These are usually of plant, animal, or fungal origin, and contain ...
A heterotroph (/ ˈ h ɛ t ər ə ˌ t r oʊ f,-ˌ t r ɒ f /; [1] [2] from Ancient Greek ἕτερος (héteros) 'other' and τροφή (trophḗ) 'nutrition') is an organism that cannot produce its own food, instead taking nutrition from other sources of organic carbon, mainly plant or animal matter. In the food chain, heterotrophs are ...