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Neonatal sepsis is a type of neonatal infection and specifically refers to the presence in a newborn baby of a bacterial blood stream infection (BSI) (such as meningitis, pneumonia, pyelonephritis, or gastroenteritis) in the setting of fever. Older textbooks may refer to neonatal sepsis as "sepsis neonatorum".
Neonatal sepsis of the newborn is an infection that has spread through the entire body. The inflammatory response to this systematic infection can be as serious as the infection itself. [ 26 ] In infants that weigh under 1500 g, sepsis is the most common cause of death.
779.81 Neonatal bradycardia; 779.82 Neonatal tachycardia; 779.83 Delayed separation of umbilical cord; 779.84 Meconium staining; 779.85 Cardiac arrest of newborn; 779.89 Other specified conditions originating in the perinatal period; 779.9 Unspecified condition originating in the perinatal period
Additional symptoms may vary based on the cause of neonatal cholestasis. For example, if a patient’s symptoms are caused by a choledochal cyst, they may present with abdominal pain, vomiting, and a palpable abdominal mass. [4] Patients with alpha-1 antitrypsin deficiency may present with hepatomegaly and elevated liver enzymes. [9]
Infants that are born at low birth weights are at risk of developing neonatal infection. [ citation needed ] Both low and high maternal serum Vitamin D (25-OH) are associated with higher incidence SGA in white women, although the correlation does not seem to hold for African American women.
Caput succedaneum is a benign neonatal condition involving a serosanguinous (containing blood and serum), subcutaneous, extra-periosteal fluid collection with poorly defined margins caused by the pressure on the presenting part of the fetal scalp by the vaginal walls and uterus as the infant passes through a narrowed cervix during delivery.
The SOFA scoring system is useful in predicting the clinical outcomes of critically ill patients. [8] According to an observational study at an Intensive Care Unit (ICU) in Belgium, the mortality rate is at least 50% when the score is increased, regardless of initial score, in the first 96 hours of admission, 27% to 35% if the score remains unchanged, and less than 27% if the score is reduced. [9]
Septic shock is a result of a systemic response to infection or multiple infectious causes. The precipitating infections that may lead to septic shock if severe enough include but are not limited to appendicitis, pneumonia, bacteremia, diverticulitis, pyelonephritis, meningitis, pancreatitis, necrotizing fasciitis, MRSA and mesenteric ischemia.
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