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Fumaric acid is (E)-1,4-but-2-enedioic acid, a trans isomer, whereas maleic acid is the corresponding cis isomer, i.e. (Z)-1,4-but-2-enedioic acid (see cis-trans isomerism). Fumaric acid has pK a values of approximately 3.0 and 4.5. By contrast, maleic acid has pK a values of approximately 1.5 and 6.5.
These findings [5] suggested that there is a PKA-dependent phase of LTP intermediate to E-LTP and L-LTP, which was called intermediate LTP (I-LTP). In the transgenic mice, on the other hand, LTP induced by two trains decayed faster than in wild-type mice, implying that excessive calcineurin activity suppresses both I-LTP and L-LTP.
The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy : a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain . [ 1 ]
It is believed that the new technology will provide not only future early diagnosis of Alzheimer's disease but also possible therapy for Alzheimer's disease. An open international study group (ND.Neuromark.net) has been constituted for arranging scientific information and developing a rational guide for implementing biomarkers into routine ...
Alzheimer's disease is a progressive neurodegenerative disorder associated with aging, which occurs both sporadically (the most common form of diagnosis) or due to familial passed mutations in genes associated with Alzheimer's pathology. [1] [2] Common symptoms associated with Alzheimer's disease include: memory loss, confusion, and mood ...
Of the donors, 51 were women and 33 men, 9 had no Alzheimer’s, 12 had low Alzheimer’s disease neuropathological changes (ADNC), 21 intermediate and 42 high ADNC.
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