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In a 2015 articles in the Journal of Urology, Thompson reported multi-parametric MRI detection of significant prostate cancer had sensitivity of 96%, specificity of 36%, negative predictive value and positive predictive values of 92% and 52%; when PI-RADS was incorporated into a multivariate analysis (PSA, digital rectal exam, prostate volume ...
Prostate MRI technology offers a detailed, high-definition view of the prostate gland. ... Recognizing their heightened risk, the guidelines recommend initiating baseline PSA testing between ages ...
To try and overcome current capacity issues with MRIs for prostate cancer, they have now set up the PRIME trial to explore whether a shorter and cheaper MRI scan could become the new standard of care.
A contrast agent usually shortens, but in some instances increases, the value of T1 of nearby water protons thereby altering the contrast in the image. Most clinically used MRI contrast agents work by shortening the T1 relaxation time of protons inside tissues via interactions with the nearby contrast agent.
Several urological societies' guidelines recommend magnetic resonance imaging (MRI) to evaluate the prostate for potential tumors in men with high PSA levels. MRI results can help distinguish those who have potentially dangerous tumors from those who do not. [26] A definitive diagnosis of prostate cancer requires a biopsy of the prostate.
The technique has demonstrated higher accuracy than other modalities in assessing seminal vesicle invasion and extra-capsular extension (ECE) of prostate cancer (96% and 81% respectively). Endorectal coil MRI is useful for determining the extent of spread and local invasion of cancers of the prostate, rectum, and anus. [2]
A study correlating MRI and surgical pathology specimens demonstrated a sensitivity of 59% and specificity of 84% in identifying cancer when T2-weighted, dynamic contrast enhanced, and diffusion-weighted imaging were used together. [10] Many prostate cancers missed by conventional biopsy are detectable by MRI-guided targeted biopsy. [11]
In MRI, while any nucleus with a net nuclear spin can be used, the proton of the hydrogen atom remains the most widely used, especially in the clinical setting, because it is so ubiquitous and returns a large signal. This nucleus, present in water molecules, allows the excellent soft-tissue contrast achievable with MRI. [6] [citation needed]
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