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The World Health Organisation has stated that depression is a leading cause of disability worldwide and a major contributor to the global burden of disease. [5] Stephen Ilardi has described depression as a "disease of civilisation", stating "We were never designed for the sedentary, indoor, sleep-deprived, socially-isolated, fast-food-laden, frenetic pace of modern life".
The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
In a single controlled study of twenty one patients, the dopamine D 3 receptor agonist pramipexole was found to be highly effective in the treatment of bipolar depression. Treatment was initiated at 0.125 mg thrice daily and increased at a rate of 0.125 mg thrice daily to a limit of 4.5 mg per day until the patients' condition satisfactorily ...
The typical course of disease is divided into three phases: at risk, acute sickness and recovery. [17] At risk individuals experience a gradual onset of symptoms over a prolonged period of time, followed by a sudden deterioration and a long recovery, with pronounced exhaustion and reduced cognitive capacity. [18]
The mechanism of action of the treatment is not clearly understood, [31] but has been shown to be most effective in the most severely depressed patients. [3] For this reason, electroconvulsive therapy is preferred for the most severe forms of depression or depression that has not responded to other treatments, known as refractory depression. [27]
We were talking earlier about mental health struggles among young people, but it's also a real concern among people who are aging — probably particularly for women, who are taught that their ...
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