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Fluid mosaic model of a cell membrane. The fluid mosaic model explains various characteristics regarding the structure of functional cell membranes.According to this biological model, there is a lipid bilayer (two molecules thick layer consisting primarily of amphipathic phospholipids) in which protein molecules are embedded.
Donnan equilibrium across a cell membrane (schematic). The Gibbs–Donnan effect (also known as the Donnan's effect, Donnan law, Donnan equilibrium, or Gibbs–Donnan equilibrium) is a name for the behaviour of charged particles near a semi-permeable membrane that sometimes fail to distribute evenly across the two sides of the membrane. [1]
It consists of two halves separated by the epithelia (sheet of mucosa or monolayer of epithelial cells grown on permeable supports). Epithelia are polar in nature, i.e., they have an apical or mucosal side and a basolateral or serosal side. An Ussing chamber can isolate the apical side from the basolateral side.
The Cell Painting assay [1] is a high-content, high-throughput imaging technique used to capture a wide array of cellular phenotypes in response to diverse perturbations. [2] These phenotypes, often termed "morphological profiles", can be used to understand various biological phenomena, including cellular responses to genetic changes, drug ...
Cross-sectional view of the structures that can be formed by phospholipids in an aqueous solution. A biological membrane, biomembrane or cell membrane is a selectively permeable membrane that separates the interior of a cell from the external environment or creates intracellular compartments by serving as a boundary between one part of the cell and another.
In 1972, S. Jonathan Singer and Garth Nicolson developed new ideas for membrane structure. Their proposal was the fluid mosaic model, which is one of the dominant models now. It has two key features—a mosaic of proteins embedded in the membrane, and the membrane being a fluid bi-layer of lipids.
A cell membrane is simplified as lipid bilayer plus membrane skeleton. The skeleton is a cross-linking protein network and joints to the bilayer at some points. Assume that each proteins in the membrane skeleton have similar length which is much smaller than the whole size of the cell membrane, and that the membrane is locally 2-dimensional ...
Cells adjust their pH i accordingly upon an increase in acidity or basicity, usually with the help of CO 2 or HCO 3 – sensors present in the membrane of the cell. [3] These sensors can permit H+ to pass through the cell membrane accordingly, allowing for pH i to be interrelated with extracellular pH in this respect.