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For example, Shigella is a longstanding World Health Organization (WHO) target for vaccine development, and sharp declines in age-specific diarrhea/dysentery attack rates for this pathogen indicate that natural immunity does develop following exposure; thus, vaccination to prevent this disease should be feasible. The development of vaccines ...
Shigella is a leading cause of bacterial diarrhea worldwide, with 80–165 million annual cases (estimated) [6] and 74,000 to 600,000 deaths. [ 6 ] [ 7 ] It is one of the top four pathogens that cause moderate-to-severe diarrhea in African and South Asian children.
Shigellosis, known historically as dysentery, is an infection of the intestines caused by Shigella bacteria. [1] [3] Symptoms generally start one to two days after exposure and include diarrhea, fever, abdominal pain, and feeling the need to pass stools even when the bowels are empty. [1]
A shigella infection can cause bloody diarrhea, fever and stomach pain, among other symptoms, making this an illness no one wants to have.
It is sometimes listed as an explicit differential diagnosis of bacillary dysentery, as opposed to a cause. [6] Bacillary dysentery should not be confused with diarrhea caused by other bacterial infections. One characteristic of bacillary dysentery is blood in stool, [7] which is the result of invasion of the mucosa by the pathogen.
Toxic megacolon paralyzes bowel movements or causes passing gas. Reactive arthritis, which is the inflammation of joints [13] Hemolytic-uremic syndrome (HUS) is a complication that occurs when bacteria enter the digestive system and produce toxins to destroy red blood cells that may cause bloody diarrhea as a symptom.
Shigella dysenteriae is a species of the rod-shaped bacterial genus Shigella. [1] Shigella species can cause shigellosis (bacillary dysentery). Shigellae are Gram-negative, non-spore-forming, facultatively anaerobic, nonmotile bacteria. [2] S. dysenteriae has the ability to invade and replicate in various species of epithelial cells and ...
As they mainly act on the lining of the blood vessels, the vascular endothelium, a breakdown of the lining and hemorrhage eventually occurs. [clarification needed] The first response is commonly a bloody diarrhea. This is because Shiga toxin is usually taken in with contaminated food or water.