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CDCA has been used as medical therapy to dissolve gallstones. [ 7 ] [ 8 ] Medical therapy with oral bile acids has been used in patients who have small cholesterol stones, and for patients with larger cholesterol gallstones who are unable or reluctant to have surgery.
The medications ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) have been used in treatment to dissolve gallstones. [58] [59] A 2013 meta-analysis concluded that UDCA or higher dietary fat content appeared to prevent formation of gallstones during weight loss. [41]
Cholelithiasis (gallstones) Can predispose to cholecystitis (gall bladder infections) and ascending cholangitis (biliary tree infection) Can progress to choledocholithiasis (gallstones in the bile duct) and gallstone pancreatitis (inflammation of the pancreas) Gastric calculi can cause colic, obstruction, torsion, and necrosis.
Biliary sludge has been associated with pregnancy, rapid weight loss, total parenteral nutrition, drugs such as ceftriaxone and octreotide, solid organ transplantation, and gastric surgery. [1] [2] In many of these conditions, it is thought that the impairment in the contractility of the gallbladder leads to the formation of the sludge. [2]
Outside the body it is used in experimental basis of cholagogues and is also in use to prevent and dissolve gallstones. [citation needed] In research deoxycholic acid is used as a mild detergent for the isolation of membrane associated proteins. The critical micelle concentration for deoxycholic acid is approximately 2.4–4 mM. [10]
In the developed world, 10 to 15% of adults have gallstones. [3] Of those with gallstones, biliary colic occurs in 1 to 4% each year. [3] Nearly 30% of people have further problems related to gallstones in the year following an attack. [3] About 15% of people with biliary colic eventually develop inflammation of the gallbladder if not treated. [3]
Atherosclerosis: Overview. This article was reviewed by Craig Primack, MD, FACP, FAAP, FOMA. Atherosclerosis happens when a fatty substance called plaque builds up inside your arteries.
Gallbladder diseases are diseases involving the gallbladder and is closely linked to biliary disease, with the most common cause being gallstones (cholelithiasis). [1] [2]The gallbladder is designed to aid in the digestion of fats by concentrating and storing the bile made in the liver and transferring it through the biliary tract to the digestive system through bile ducts that connect the ...
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