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Sedation, respiratory depression and hypotension due to a reduction in systematic vascular resistance, and an increase in heart rate can occur. [23] [41] If intravenous midazolam is given too quickly, hypotension may occur. A "midazolam infusion syndrome" may result from high doses, is characterised by delayed arousal hours to days after ...
Variation in potency of certain effects may exist amongst individual benzodiazepines. Some benzodiazepines produce active metabolites. Active metabolites are produced when a person's body metabolizes the drug into compounds that share a similar pharmacological profile to the parent compound and thus are relevant when calculating how long the ...
Goldstein agrees, saying, “Heart rate variability with exercise, and during recovery after exercise is a better predictor of overall health.” ...
Heart rate variability visualized with R-R interval changes Electrocardiogram (ECG) recording of a canine heart that illustrates beat-to-beat variability in R–R interval (top) and heart rate (bottom). Heart rate variability (HRV) is the physiological phenomenon of variation in the time interval between heartbeats. It is measured by the ...
The rate of dosage reduction is best carried out so as to minimize the symptoms' intensity and severity. Anecdotally, a slow rate of reduction may reduce the risk of developing a severe protracted syndrome. Long half-life benzodiazepines like diazepam [1] or chlordiazepoxide are preferred to minimize rebound effects and are available in low ...
Trouble is, ongoing stress can take a toll on our heart health since it increases heart rate and blood pressure. It can also prompt our bodies to release stress hormones like cortisol and adrenaline.
Close monitoring by the anesthesia provider will sometimes be provided, to help keep the patient comfortable during a medical procedure, along with other drugs to help relax the body. It can also help control breathing, blood pressure, blood flow, and heart rate and rhythm, when needed. [1] There are four levels of sedation by anesthesia.
In most cases, vagal tone is not measured directly. Instead the processes affected by the vagus nerve – specifically heart rate and heart rate variability – are measured and used as a surrogate for vagal tone. Increased vagal tone (and thus vagal action) is generally associated with a lower heart rate and increased heart rate variability.