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Topical glucocorticoid phobia is a concern or fear about using topical glucocorticoids, which is commonly found among patients with atopic dermatitis and their caregivers. [29] This phenomenon has been identified in more than 15 countries globally, including Canada , France , Japan , the United Kingdom , and the United States . [ 30 ]
Glucocorticoid drugs currently being used act nonselectively, so in the long run they may impair many healthy anabolic processes. To prevent this, much research has been focused recently on the elaboration of selectively acting glucocorticoid drugs. Side effects include: Immunodeficiency (see section below)
Micrograph of fatty liver, as may be seen due to long-term prednisone use. Trichrome stain.. Short-term side effects, as with all glucocorticoids, include high blood glucose levels (especially in patients with diabetes mellitus or on other medications that increase blood glucose, such as tacrolimus) and mineralocorticoid effects such as fluid retention. [24]
Methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol) is a synthetic glucocorticoid, primarily prescribed for its anti-inflammatory and immunosuppressive effects. [4] [5] [6] It is either used at low doses for chronic illnesses or used concomitantly at high doses during acute flares.
In rare cases, Fluticasone furoate may cause more serious side effects, such as adrenal suppression, glaucoma, cataracts, or growth retardation in children. These side effects are more likely to occur with long-term, high-dose use, although they are still rare. [18] Serious side effects of Fluticasone Furoate include: hives, difficulty breathing,
higher potency corticosteroids, more frequent application, extended duration of treatment, [3] use of occlusion, infancy/childhood, location [2] Diagnostic method: Visual inspection of skin for visible signs of skin atrophy [1] Prevention: Intermittent maintenance therapy; increasing duration of interval between applications [4] Management
Common side effects when inhaled include upper respiratory tract infections, sinusitis, thrush, and cough. [8] Common side effects when used in the nose include nosebleeding and sore throat. [ 9 ] Unlike fluticasone furoate , which is approved in children as young as two years of age when used for allergies, fluticasone propionate is only ...
Ocular effects: Topical steroid drops are frequently used after eye surgery but can also raise intraocular pressure (IOP) and increase the risk of glaucoma, cataract, retinopathy as well as systemic adverse effects. [14] Tachyphylaxis: The acute development of tolerance to the action of a drug after repeated doses. [15]