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  2. Electrospray ionization - Wikipedia

    en.wikipedia.org/wiki/Electrospray_ionization

    Electrospray ionization (ESI) is a technique used in mass spectrometry to produce ions using an electrospray in which a high voltage is applied to a liquid to create an aerosol. It is especially useful in producing ions from macromolecules because it overcomes the propensity of these molecules to fragment when ionized.

  3. Time-of-flight mass spectrometry - Wikipedia

    en.wikipedia.org/wiki/Time-of-flight_mass...

    Laser ionization time-of-flight mass spectrometer where ions are accelerated and separated by mass in a field-free drift region before detection Bendix MA-2 Time-of-Flight Mass Spectrometer, 1960s. Time-of-flight mass spectrometry (TOFMS) is a method of mass spectrometry in which an ion's mass-to-charge ratio is determined by a time of flight ...

  4. Electron ionization - Wikipedia

    en.wikipedia.org/wiki/Electron_ionization

    Electron ionization. Electron ionization (EI, formerly known as electron impact ionization [1] and electron bombardment ionization [2]) is an ionization method in which energetic electrons interact with solid or gas phase atoms or molecules to produce ions. [3] EI was one of the first ionization techniques developed for mass spectrometry. [4]

  5. Protonation - Wikipedia

    en.wikipedia.org/wiki/Protonation

    Upon protonating a substrate, the mass and the charge of the species each increase by one unit, making it an essential step in certain analytical procedures such as electrospray mass spectrometry.

  6. Proteomics - Wikipedia

    en.wikipedia.org/wiki/Proteomics

    Proteomics generally denotes the large-scale experimental analysis of proteins and proteomes, but often refers specifically to protein purification and mass spectrometry. Indeed, mass spectrometry is the most powerful method for analysis of proteomes, both in large samples composed of millions of cells [5] and in single cells. [6] [7]

  7. Nicotinamide adenine dinucleotide - Wikipedia

    en.wikipedia.org/wiki/Nicotinamide_adenine_di...

    Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism. [3] Found in all living cells, NAD is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups.

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