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Researchers say the findings support the possibility the drug could be a preventative treatment for the condition.
Certain lithium compounds, also known as lithium salts, are used as psychiatric medication, [5] primarily for bipolar disorder and for major depressive disorder. [5] Lithium is taken orally (by mouth). [5] Common side effects include increased urination, shakiness of the hands, and increased thirst. [5]
Lithium treatment has been shown to reduce the density of neurofibrillary tangles in transgenic models in the hippocampus and spinal cord. Despite the decrease in density of NFTs, motor and memory deficits were not seen to improve following treatment. Additionally, no preventive effects have been seen in patients undergoing lithium treatment. [22]
Lithium is readily absorbed from the gastrointestinal tract. [5] It is distributed to the body with higher levels in the kidney, thyroid, and bone as compared to other tissues. Since lithium is almost exclusively excreted by the kidneys, people with preexisting chronic kidney disease are at high risk of developing lithium intoxication. [13]
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