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The William Lynch speech, also known as the Willie Lynch letter, is an address purportedly delivered by a William Lynch (or Willie Lynch) to an audience on the bank of the James River in Virginia in 1712 regarding control of slaves within the colony. [1] In recent years, it has been widely exposed as a hoax. [2] [3]
Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.. HNPCC includes (and was once synonymous with) [1] Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. [2]
MUTYH-associated polyposis (also known as MYH-associated polyposis) is an autosomal recessive polyposis syndrome. [1] The disorder is caused by mutations in both alleles (genetic copies) of the DNA repair gene, MUTYH. The MUTYH gene encodes a base excision repair protein, which corrects oxidative damage to DNA.
At least 2 successive generations involved; At least 1 of the cancers diagnosed before age 50. [5] These criteria were found to be too strict and were expanded to include the associated non-colorectal cancers in 1998. These were called the Amsterdam II clinical criteria for families with Lynch syndrome. [4] [6]
An enslaver by the name of Willie Lynch was said to have allegedly written a pamphlet that widely circulated instructing enslavers on how to use brutality to control enslaved people. "The Willie ...
Variants in this gene can cause hereditary nonpolyposis colon cancer (Lynch syndrome). It is a human homolog of the E. coli DNA mismatch repair gene, mutL, which mediates protein-protein interactions during mismatch recognition, strand discrimination, and strand removal.
Under the name constitutional mismatch repair-deficiency (CMMR-D), it has been mapped to MLH1, MSH2, MSH6 or PMS2. [2] Monoallelic mutations of these genes are observed in the condition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer, while biallelic mutations are observed in CMMR-D. [3] People expressing the HNPCC (which itself is considered autosomal dominant) trait are ...
The Urdu Wikipedia (Urdu: اردو ویکیپیڈیا), started in January 2004, is the Standard Urdu-language edition of Wikipedia, a free, open-content encyclopedia. [1] [2] As of 1 March 2025, it has 218,309 articles, 191,144 registered users and 7,561 files, and it is the 54th largest edition of Wikipedia by article count, and ranks 20th in terms of depth among Wikipedias with over 150,000 ...