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The William Lynch speech, also known as the Willie Lynch letter, is an address purportedly delivered by a William Lynch (or Willie Lynch) to an audience on the bank of the James River in Virginia in 1712 regarding control of slaves within the colony. [1] In recent years, it has been widely exposed as a hoax. [2] [3]
Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.. HNPCC includes (and was once synonymous with) [1] Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. [2]
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At least 2 successive generations involved; At least 1 of the cancers diagnosed before age 50. [5] These criteria were found to be too strict and were expanded to include the associated non-colorectal cancers in 1998. These were called the Amsterdam II clinical criteria for families with Lynch syndrome. [4] [6]
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Charles Lynch's extralegal actions were legitimized by the Virginia General Assembly in 1782. [1] In 1811, Captain William Lynch claimed that the phrase "Lynch's Law", already famous, actually came from a 1780 compact signed by him and his neighbours in Pittsylvania County, Virginia, to uphold their own brand of law independent of legal authority.
Under the name constitutional mismatch repair-deficiency (CMMR-D), it has been mapped to MLH1, MSH2, MSH6 or PMS2. [2] Monoallelic mutations of these genes are observed in the condition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer, while biallelic mutations are observed in CMMR-D. [3] People expressing the HNPCC (which itself is considered autosomal dominant) trait are ...
William Lynch (diplomat) (c. 1730–1785), British Member of Parliament for Canterbury and Minister to Sardinia; William Lynch (Lynch law) (1742–1820), claimed to be the basic cause of the "lynch law" term; William Lynch (Maryland politician) (1788–1857), American politician from Maryland; William A. Lynch (1844–1907), Ohio lawyer and ...