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Its side-effect profile indicates that it possesses clinically relevant glucocorticoid activity. [11] [10] An active metabolite of osaterone acetate, 15β-hydroxyosaterone acetate, has potent antiandrogenic activity similarly to osaterone acetate. [3] Osaterone acetate treats BPH in dogs by reducing the actions of androgens in the prostate ...
Mifepristone, and also known by its developmental code name RU-486, is a drug typically used in combination with misoprostol to bring about a medical abortion during pregnancy. [8] This combination is 97% effective [ 9 ] during the first 63 days (9 weeks) of pregnancy , yet effective in the second trimester as well.
Aglepristone (INN Tooltip International Nonproprietary Name) (brand name Alizin; former developmental code names RU-46534, RU-534) is a synthetic, steroidal antiprogestogen related to mifepristone which is marketed by Virbac in several European countries for use in veterinary medicine. [1] [2] [3] It is specifically used as an abortifacient in ...
Danco Laboratories, a manufacturer of the abortion drug mifepristone, has asked the Supreme Court to reverse a lower court ruling that would restrict access to the drug; the justices could make ...
Mifepristone (RU-486; Mifegyne, Mifeprex): An antiprogestogen which is widely used as an abortifacient. Also has antiglucocorticoid and AR antagonist activity. Has been found to produce gynecomastia as a side effect in men at a relatively high rate in clinical studies. Has been studied as a treatment for prostate cancer.
Antiprogestogens are used as abortifacients, emergency contraceptives, and in the treatment of uterine fibroids. They are also being studied in the treatment of breast cancer . Examples include the progesterone receptor weak partial agonist mifepristone , the selective progesterone receptor modulator (SPRM) ulipristal acetate , and the silent ...
Disadvantages of mitotane as a treatment include the side effects and the requirement for blood test monitoring. Issues can arise when too much of the adrenal cortex becomes eroded. Approximately 30% of dogs will experience a reaction in response to treatment with mitotane; prednisone may be used as an antidote. In the event of a reaction ...
For pregnancies after 9 weeks, two doses of misoprostol (the second drug) makes the treatment more effective. [21] From 10 to 11 weeks of pregnancy, the National Abortion Federation suggests second dose of misoprostol (800 micrograms) four hours after the first dose. [22] After the patient takes mifepristone, they must also administer the ...