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Common side effects include vomiting, diarrhea, rash, and increased liver enzymes. [5] Serious side effects may include liver problems, QT prolongation, and seizures. [5] During pregnancy it may increase the risk of miscarriage while large doses may cause birth defects. [6] [5] Fluconazole is in the azole antifungal family of medication. [5]
For patients who cannot tolerate oral medication, IV fluconazole can be used alternatively. [3] Other oral triazoles, such as itraconazole and voriconazole can be other options. [3] Amphotericin B can be used in nonresponsive cases, but should not be used routinely due to its serious side effects. [3]
The most common side effects include abnormal liver tests, nausea, vomiting, difficulty breathing, abdominal pain, diarrhea, injection site reactions, headache, low blood potassium and skin rash. [10] Isavuconazonium is a prodrug of isavuconazole. [13]
The side effects of oral treatment are significant and people without an infection should not take these drugs. [36] Azoles are the group of antifungals which act on the cell membrane of fungi. They inhibit the enzyme 14-alpha-sterol demethylase, a microsomal CYP, which is required for the biosynthesis of ergosterol for the cytoplasmic membrane.
Common side effects when taken by mouth include nausea, headache, and liver problems. [11] Liver problems may result in death or the need for a liver transplantation. [11] [13] Other severe side effects when taken by mouth include QT prolongation, adrenocortical insufficiency, and anaphylaxis.
Symptoms and their severities are unknown, because flucytosine is used under close medical supervision, but expected to be an excess of the usually encountered side effects on the bone marrow, gastrointestinal tract, liver and kidney function. Vigorous hydration and hemodialysis may be helpful in removing the drug from the body. Hemodialysis is ...
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.
Common side effects when applied to the skin include burning, itching, and a rash. [1] Common side effects when taken by mouth include vomiting and diarrhea. [1] During pregnancy use in the vagina is safe while other formulations have not been studied in this group. [1] It works by disrupting the cell membrane of the fungal cells. [1]
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