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Arsphenamine, also known as Salvarsan or compound 606, is an antibiotic drug that was introduced at the beginning of the 1910s as the first effective treatment for the deadly infectious diseases syphilis, relapsing fever, and African trypanosomiasis. [2] [3] This organoarsenic compound was the first modern antimicrobial agent. [4]
After convincing clinical trials, the compound number 606 was given the trade name "Salvarsan", a portmanteau for "saving arsenic". [2] Salvarsan was commercially introduced in 1910, and in 1913, a less toxic form, "Neosalvarsan" (Compound 914), was released in the market.
Release date. February 23, 1940 () Running time ... and after 606 tries he finally discovers the remedy for the disease. ... first called "606", then Salvarsan, ...
Paul Ehrlich (German: [ˈpaʊl ˈʔeːɐ̯lɪç] ⓘ; 14 March 1854 – 20 August 1915) was a Nobel Prize-winning German physician and scientist who worked in the fields of hematology, immunology and antimicrobial chemotherapy.
When Hata injected compound 606, arsphenamine, into rabbits infected with syphilis, he found it to be effective against syphilis in vivo. [2] [6] It was called compound 606 because it was the 606th compound that Ehrlich and Hata tested. Arsphenamine was first thought to be ineffective when it was tested by Ehrlich's former assistants, so their ...
1911 – Arsphenamine, also Salvarsan [1] 1912 – Neosalvarsan; 1935 – Prontosil (an oral precursor to sulfanilamide), the first sulfonamide; 1936 – Sulfanilamide; 1938 – Sulfapyridine (M&B 693) 1939 – sulfacetamide; 1940 – sulfamethizole; 1942 – benzylpenicillin, the first penicillin; 1942 – gramicidin S, the first peptide ...
The first effective treatment, Salvarsan, was developed in 1910 by Sahachiro Hata in the laboratory of Paul Ehrlich. It was followed by the introduction of penicillin in 1943. [2] Many well-known figures, including Scott Joplin, Franz Schubert, Friedrich Nietzsche, Al Capone, and Édouard Manet are believed to have contracted the disease. [2]
The drug in the kit was made by a German manufacturer Farbwerke vorm Meister Lucius & Bruning AG and is stamped with the date “3 February 1912”. It was sold by a British chemist, W Martindale, who added all the equipment to prepare injections. maker (Salvarsan): Farbwerke vorm Meister Lucius und Brüning, supplier: W Martindale