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Anti-Deoxyribonuclease B (anti-DNase B) titres are a quantitative measure of the presence of serologic antibodies obtained from patients suspected of having a recent group A (Beta-hemolytic) streptococcus bacteria infection, from Streptococcus pyogenes.
Anti-streptolysin O (ASO), anti-DNase B Confirmed Declining due to improved treatment of strep throat [30] Kawasaki disease: Coronary arteries: Unknown Probable 20 per 100,000 children under age 5 [31] Giant cell arteritis: Large and medium arteries, can affect coronary arteries None specific Confirmed 200 per 100,000 (over age 50) [32] [33]
Anti-DNAse B titre (peaks at 8–12 weeks after infection) Anti-streptolysin O titre (peaks at 3–5 weeks) None of these tests are 100% reliable, particularly when the infection was some months previously. Further testing is directed more towards alternative diagnoses and other manifestations of rheumatic fever: Echocardiography
DNase I Structure: DNase I is a glycoprotein with a molecular weight of 30,000 Da and a carbohydrate chain of 8-10 residues attached to Asn18 (orange). [3] It is an 𝛼,𝛽-protein with two 6-stranded 𝛽-pleated sheets which form the core of the structure. [ 4 ]
Anti-CEA antibody; Anti-cholesterol; Anti-DNase B; Anti-immunoglobulin; Anti-LKM antibody; Anti-streptolysin O; Antibody testing; Antinuclear antibody; Antisperm antibodies; Antithyroid autoantibodies; Autoantibody
Streptococcus pyogenes is a species of Gram-positive, aerotolerant bacteria in the genus Streptococcus.These bacteria are extracellular, and made up of non-motile and non-sporing cocci (round cells) that tend to link in chains.
In the 1970s, the anti-Ro/anti-SS-A and anti-La/anti-SS-B antibodies were discovered. The Scl-70 antibody was known to be a specific antibody to scleroderma in 1979, however the antigen (topoisomerase-I) was not characterised until 1986.
The associated anti-A and anti-B antibodies are usually IgM antibodies, produced in the first years of life by sensitization to environmental substances such as food, bacteria, and viruses. The ABO blood types were discovered by Karl Landsteiner in 1901; he received the Nobel Prize in Physiology or Medicine in 1930 for this discovery. [ 5 ]