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Primidone, sold under various brand names (including Mysoline), is a barbiturate medication that is used to treat partial and generalized seizures [7] and essential tremors. [8] It is taken by mouth. [7] Its common side effects include sleepiness, poor coordination, nausea, and loss of appetite. [7] Severe side effects may include suicide and ...
Use of anticonvulsant medications should be carefully monitored during use in pregnancy. [94] For example, since the first trimester is the most susceptible period for fetal development, planning a routine antiepileptic drug dose that is safer for the first trimester could be beneficial to prevent pregnancy complications.
Levetiracetam, sold under the brand name Keppra among others, is a novel antiepileptic drug [7] used to treat epilepsy. [8] It is used for partial-onset, myoclonic, or tonic–clonic seizures, [7] and is taken either by mouth as an immediate or extended release formulation or by injection into a vein.
It is primarily effective in treating absence seizures, but can also be used in refractory temporal lobe epilepsy. It is usually administered 3 or 4 times daily, with the total daily dose ranging from 900 mg to 2.4 g. Treatment is most effective when the concentration of its active metabolite, dimethadione, is above 700 μg/mL.
Knowing the indication of the drug can also help providers determine if the dose of the drug is appropriate per indication, and this can greatly improve patient safety and drug effectiveness. [ 28 ] However, there are still some challenges with incorporating the indication of use on prescription drug labels.
Vilazodone was approved for medical use in the United States in 2011 [1] and in Canada in 2018. [8] In 2019, it was the 334th most commonly prescribed medication in the United States, with more than 900 thousand prescriptions. [9] The drug lost patent protection in June 2022 for adults and in July 2023 for pediatrics. [10]
Amisulpride is approved and used at low doses in the treatment of dysthymia and major depressive disorder. [10] [20] [11] [21] [22] [23] Whereas typical doses used in schizophrenia block postsynaptic dopamine D 2-like receptors and reduce dopaminergic neurotransmission, low doses of amisulpride preferentially block presynaptic dopamine D 2 and D 3 autoreceptors and thereby disinhibit dopamine ...
Tiotixene is a widely used drug for the treatment of various psychiatric disorders such as schizophrenia, bipolar disorder, mania, and behavioural disturbances. [7] The drug regulates behaviour and thoughts, and can also exhibit an anti-depressive effect. [3] [8]