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Benzimidazole was discovered during research on vitamin B 12. The benzimidazole nucleus was found to be a stable platform on which drugs could be developed. [3] Benzimidazole is produced by condensation of o-phenylenediamine with formic acid, [4] or the equivalent trimethyl orthoformate: C 6 H 4 (NH 2) 2 + HC(OCH 3) 3 → C 6 H 4 N(NH)CH + 3 CH ...
The structure-activity relationship of the drug class has been explored to a reasonable extent. The optimal substitution pattern is fairly tightly defined (i.e. N,N-diethyl on the amine nitrogen, 4-ethoxy on the benzyl ring and 5-nitro on the benzimidazole ring), but even derivatives incorporating only some of these features are still potent opioids.
Benznidazole is an antiparasitic medication used in the treatment of Chagas disease. [2] While it is highly effective in early disease, the effectiveness decreases in those who have long-term infection. [3] It is the first-line treatment given its moderate side effects compared to nifurtimox. [1] It is taken by mouth. [2] Side effects are ...
Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. [3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.
Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles, and strongyloides that can be administered to sheep, cattle, horses, fish, dogs, cats ...
Isotonitazene is a benzimidazole-derived opioid analgesic drug related to etonitazene, [3] [4] [5] which has been sold as a designer drug. [6] [7] [8] It has only ...
Melarsoprol (for treatment of sleeping sickness caused by Trypanosoma brucei) Eflornithine (for sleeping sickness) Metronidazole (for vaginitis caused by Trichomonas) Tinidazole (for intestinal infections caused by Giardia lamblia) Miltefosine (for the treatment of visceral and cutaneous leishmaniasis, currently undergoing investigation for ...
Etonitazene, also known as EA-4941 or CS-4640, [2] is a benzimidazole opioid, first reported in 1957, [3] that has been shown to have approximately 1,000 to 1,500 times the potency of morphine in animals.
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