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Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines, the oral route is unsuitable for certain substances, such as salvinorin A .
Granular cell tumour: These are also tumours arising from neural cells, though it was incorrectly thought to arise from muscle cells and therefore previously called granular cell myoblastoma. It also is slow growing large painless and occurs mostly in the tongue.
The floor is formed by the mylohyoid muscles and is occupied mainly by the anterior two-thirds of the tongue. A mucous membrane – the oral mucosa, lines the sides and under surface of the tongue to the gums, and lines the inner aspect of the jaw . It receives secretions from the submandibular and sublingual salivary glands.
Each acinus is located at the terminal part of the gland connected to the ductal system, with many acini within each lobule of the gland. Each acinus consists of a single layer of cuboidal epithelial cells surrounding a lumen, a central opening where the saliva is deposited after being produced by the secretory cells.
Sublingual administration is when medication is placed under the tongue to be absorbed by the body. The word "sublingual" means "under the tongue." Buccal administration involves placement of the drug between the gums and the cheek. These medications can come in the form of tablets, films, or sprays.
These tonsils contain B and T lymphocytes which get activated when harmful bacteria and viruses come in contact with tonsils. B lymphocytes kill pathogens by producing antibodies against them, while T lymphocytes directly kill them releasing cytotoxic substances or indirectly by stimulating other cells of the immune system. [2] [3] [4]
Located underneath the oral diaphragm (diaphragma oris), the sublingual gland is the smallest and most diffuse of the three major salivary glands of the oral cavity, with the other two being the submandibular and parotid. The sublingual gland provides approximately 3-5% of the total salivary volume. [1] [2]
The ratio between myeloid series and erythroid cells is relevant to bone marrow function, and also to diseases of the bone marrow and peripheral blood, such as leukemia and anemia. The normal myeloid-to-erythroid ratio is around 3:1; this ratio may increase in myelogenous leukemias , decrease in polycythemias , and reverse in cases of thalassemia .