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  2. Platelet - Wikipedia

    en.wikipedia.org/wiki/Platelet

    The term thrombocyte (clot cell) came into use in the early 1900s and is sometimes used as a synonym for platelet; but not generally in the scientific literature, except as a root word for other terms related to platelets (e.g. thrombocytopenia meaning low platelets). [4]: v3 The term thrombocytes are proper for mononuclear cells found in the ...

  3. Coagulation - Wikipedia

    en.wikipedia.org/wiki/Coagulation

    The GP1b-IX receptor complex. This protein receptor complex is found on the surface of platelets, and in conjunction with GPV allows for platelets to adhere to the site of injury. Mutations in the genes associated with the glycoprotein Ib-IX-V complex are characteristic of Bernard–Soulier syndrome.

  4. Procoagulant platelets - Wikipedia

    en.wikipedia.org/wiki/Procoagulant_platelets

    Procoagulant platelets are a functional subgroup of platelets with distinct properties in physiological haemostasis. Following strong activation, procoagulant platelets express phosphatidylserine on their surface and become highly efficient in sustaining thrombin generation and parallelly gain pro-haemostatic function by retaining α-granule proteins on their membranes. [1]

  5. Fibrin - Wikipedia

    en.wikipedia.org/wiki/Fibrin

    The polymerized fibrin, together with platelets, forms a hemostatic plug or clot over a wound site. When the lining of a blood vessel is broken, platelets are attracted, forming a platelet plug . These platelets have thrombin receptors on their surfaces that bind serum thrombin molecules, [ 1 ] which in turn convert soluble fibrinogen in the ...

  6. Thrombopoiesis - Wikipedia

    en.wikipedia.org/wiki/Thrombopoiesis

    Platelets are regulators of hemostasis and thrombosis. Platelets become active in the blood following vascular injury. Vascular injury causes platelets to stick to the cellular matrix that is exposed under the endothelium, form a platelet plug, and then form a thrombus. Platelets are essential in the formation of an occlusive thrombus and are ...

  7. Thrombopoietin - Wikipedia

    en.wikipedia.org/wiki/Thrombopoietin

    Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. [6]

  8. P-selectin - Wikipedia

    en.wikipedia.org/wiki/P-selectin

    P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. [5]P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets.

  9. CD36 - Wikipedia

    en.wikipedia.org/wiki/CD36

    Using Kyte–Doolittle analysis, [25] the amino acid sequence of CD36 predicts a hydrophobic region near each end of the protein large enough to span cellular membranes.Based on this notion and the observation that CD36 is found on the surface of cells, CD36 is thought to have a 'hairpin-like' structure with α-helices at the C- and N- termini projecting through the membrane and a larger ...