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Scurvy is a deficiency disease (state of malnutrition) resulting from a lack of vitamin C (ascorbic acid). [1] Early symptoms of deficiency include weakness, fatigue, and sore arms and legs. [1] [2] Without treatment, decreased red blood cells, gum disease, changes to hair, and bleeding from the skin may occur.
The design for a medical study in 1743 that was never carried out may have inspired James Lind’s groundbreaking clinical trial that determined the treatment for scurvy. A 1747 study found the ...
James Lind FRSE FRCPE (4 October 1716 – 13 July 1794) was a Scottish physician. He was a pioneer of naval hygiene in the Royal Navy.By conducting one of the first ever clinical trials, [1] [2] [3] he developed the theory that citrus fruits cured scurvy.
Vitamin C is an essential nutrient used in the production of collagen and other biomolecules, and for the prevention of scurvy. [6] It is also an antioxidant, which has led to its endorsement by some researchers as a complementary therapy for improving quality of life. [7]
During March through July 2020, vitamin C was the subject of more US FDA warning letters than any other ingredient for claims for prevention and/or treatment of COVID-19. [124] In April 2021, the US National Institutes of Health (NIH) COVID-19 Treatment Guidelines stated that "there are insufficient data to recommend either for or against the ...
Untreated, consequences can cause brain damage or death. The prevalence of VKDB is reported at 0.25 to 1.7%, with higher risk in Asian populations. The recommended prevention treatment is an intramuscular injection of 1 mg of vitamin K at birth (called the Vitamin K shot.). [52]
In-hospital treatment often involves managing low blood sugar, maintaining adequate body temperature, addressing dehydration, and gradual feeding. [ 7 ] [ 160 ] Routine antibiotics are usually recommended because malnutrition weakens the immune system, causing a high risk of infection. [ 160 ]
The first reported clinical trial is conducted by James Lind in 1747 to identify treatment for scurvy. [13] [14] Scurvy: 1796: Discovery: The smallpox vaccine is the first successful vaccine to be developed, introduced by scientist Edward Jenner.