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Citalopram, sold under the brand name Celexa among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [ 7 ] [ 10 ] It is used to treat major depressive disorder , obsessive compulsive disorder , panic disorder , and social phobia . [ 7 ]
MDMA/citalopram is a combination of the entactogen and monoamine releasing agent 3,4-methylenedioxymethamphetamine (MDMA; also known as midomafetamine or "ecstasy") and the selective serotonin reuptake inhibitor (SSRI) citalopram which is under development for the treatment of post-traumatic stress disorder (PTSD). [1] [2] [3]
Tactogen is additionally studying a combination of MDMA and citalopram wherein MDMA is followed by the selective serotonin reuptake inhibitor (SSRI) citalopram in efforts to reduce the serotonergic neurotoxicity and negative after-effects of MDMA. [7] [25] [23] [26] A phase 2 trial of this strategy is planned to commence in 2025.
Andersen et al. were able to generate a model of the (S)-citalopram binding site in human SERT by combining mutational analysis and comparative modeling where they found out that Asn-177 and Phe-341 where key determinants for (S)-citalopram potency and high affinity inhibition [47] in addition to Tyr-95, Asp-98, Ile-172 and Ser438 previously ...
Celexa – an antidepressant of the SSRI class; Centrax – an anti-anxiety agent; Clozaril – atypical antipsychotic used to treat resistant schizophrenia; Concerta (methylphenidate) – an extended release form of methylphenidate
Escitalopram is the (S)-enantiomer of citalopram (which exists as a racemate), hence the name es-citalopram. [9] Escitalopram was approved for medical use in the United States in 2002. [9] Escitalopram is rarely replaced by twice the dose of citalopram; escitalopram is safer and more effective. [11]
Citalopram is a racemic mixture (50/50), and the inhibition of 5-HT reuptake by citalopram is primarily due to the (S)-enantiomer. [1] Citalopram has no or very low affinity for 5-HT 1a 5-HT 2a, dopamine D 1 and D 2, α 1-, α 2-, and β-adrenergic, histamine H 1, gamma aminobutyric acid (GABA), muscarinic cholinergic, and benzodiazepine ...
Didesmethylescitalopram is an active metabolite of the antidepressant escitalopram, the S-enantiomer of citalopram. Like citalopram and escitalopram, didesmethyl(es)citalopram functions as a selective serotonin reuptake inhibitor (SSRI), and is responsible for some of its parents' therapeutic benefits .