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Vibegron, sold under the brand name Gemtesa, is a medication for the treatment of overactive bladder. [1] [5] [6] Vibegron is a selective beta-3 adrenergic receptor agonist. [1] The most common side effects include headache, urinary tract infection, common cold, diarrhea, nausea, and upper respiratory tract infection. [5]
The chemical structure of vibegron, a β 3-adrenergic receptor agonist. In 2018 two other β 3-AR agonists are in clinical trials, vibegron and solabegron. Vibegron is in phase 3 clinical trial and is used to treat OAB. [3] Solabegron is in phase 2b clinical trials to treat OAB in women and in phase 1 clinical trials in men to treat OAB. [4] [5]
Urovant Sciences, a wholly-owned subsidiary of Sumitovant Biopharma Ltd, announced the publication of a new review of data on Gemtesa (vibegron) 75 mg in the peer-reviewed journal, Therapeutics ...
A combination of mirabegron and metformin was studied in mice and caused greater weight loss than either drug alone. [15] A human study in obese individuals found an increase in insulin sensitivity but no significant weight change, which was hypothesized to be due to low levels of BAT in obese humans and/or the low dose of mirabegron used in ...
Solabegron (code name GW-427,353) is a drug which acts as a selective agonist for the β 3 adrenergic receptor. It is being developed for the treatment of overactive bladder and irritable bowel syndrome. [1] [2] [3] It has been shown to produce visceral analgesia by releasing somatostatin from adipocytes. [4] [5]
Democratic Sen. Dianne Feinstein’s office said Thursday that she is suffering from Ramsay Hunt syndrome, a complication from the shingles virus that can paralyze part of the face, and that she ...
Zycosan, for horses, is a heparin-like compound and is the first injectable pentosan product to receive approval by the US Food and Drug Administration (FDA). [ 21 ] In December 2022, the US Food and Drug Administration (FDA) approved pentosan polysulfate (Zycosan) for the control of clinical signs associated with osteoarthritis in horses. [ 21 ]
The most common side effects of tramadol in order of decreasing incidence are: [1] [2 ... Serious adverse effects are in bold. Very common (>10% frequency) ...