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The influenza viral genome is composed of eight ribonucleoprotein particles formed by a complex of negative-sense RNA bound to a viral nucleoprotein. Each RNP carries with it an RNA polymerase complex. When the nucleoprotein binds to the viral RNA, it is able to expose the nucleotide bases which allow the viral polymerase to transcribe RNA. At ...
Influenza virus nucleoprotein (NP) is a structural protein which encapsidates the negative strand viral RNA.NP is one of the main determinants of species specificity. The question of how far the NP gene can cross the species barrier by reassortment and become adapted by mutation to the new host has been discussed.
The most abundant protein produced is the nucleoprotein, whose concentration in the cell determines when the RdRp switches from gene transcription to genome replication. [ 9 ] Replication results in full-length, positive-stranded antigenomes that are in turn transcribed into negative-stranded virus progeny genome copies.
The nucleocapsid (N) protein is a protein that packages the positive-sense RNA genome of coronaviruses to form ribonucleoprotein structures enclosed within the viral capsid. [ 2 ] [ 3 ] The N protein is the most highly expressed of the four major coronavirus structural proteins . [ 2 ]
In the cytoplasm, ribosomal RNA and protein combine to form a nucleoprotein called a ribosome. The ribosome binds mRNA and carries out protein synthesis. Several ribosomes may be attached to a single mRNA at any time. [27] Nearly all the RNA found in a typical eukaryotic cell is rRNA. Transfer-messenger RNA (tmRNA) is found in many bacteria and ...
Since most mature RNA is exported from the nucleus relatively quickly, most RNA-binding protein in the nucleus exist as heterogeneous ribonucleoprotein particles. After splicing has occurred, the proteins remain bound to spliced introns and target them for degradation.
Nucleoporin protein aladin is a component of the nuclear pore complex. Mutations in the aladin gene are responsible for triple-A syndrome, an autosomal recessive neuroendocrinological disease. Mutant aladin causes selective failure of nuclear protein import and hypersensitivity to oxidative stress. [19]
19361 Ensembl ENSG00000051180 n/a UniProt Q06609 Q08297 RefSeq (mRNA) NM_001164269 NM_001164270 NM_002875 NM_133487 NM_011234 RefSeq (protein) NP_001157741 NP_001157742 NP_002866 NP_597994 NP_035364 Location (UCSC) Chr 15: 40.69 – 40.73 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded ...