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Periods when gout symptoms are more severe are called gout flares or gout attacks. A gout flare comes on suddenly, and symptoms are often intense. ... an immunosuppressant drug, and diuretics ...
Colchicine is typically prescribed to mitigate or prevent the onset of gout, or its continuing symptoms and pain, using a low-dose prescription of 0.6 to 1.2 mg per day, or a high-dose amount of up to 4.8 mg in the first 6 hours of a gout episode. [13] [25] With an oral dose of 0.6 mg, peak blood levels occur within one to two hours. [50]
Naproxen is not contraindicated in the presence of SSRIs, though concomitant use of the medications should be done with caution. [32] Alcohol consumption increases the risk of gastrointestinal bleeding when combined with NSAIDs like naproxen in a dose-dependent manner (that is, the higher the dose of naproxen, the higher the risk of bleeding). [33]
Levels that cannot be brought below 6.0 mg/dL while attacks continue indicates refractory gout. [67] While historically it is not recommended to start allopurinol during an acute attack of gout, this practice appears acceptable. [68] Allopurinol blocks uric acid production, and is the most commonly used agent. [20]
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Some COX-2 inhibitors are used in a single dose to treat pain after surgery. [5] [6] In this role etoricoxib appears as good as, if not better than, other pain medications, and celecoxib appears to be about as useful as ibuprofen. [7] [8] NSAIDs are often used in treatment of acute gout attacks.
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