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These three databases are primary databases, as they house original sequence data. They collaborate with Sequence Read Archive (SRA), which archives raw reads from high-throughput sequencing instruments. Secondary databases are: [clarification needed] 23andMe's database; HapMap; OMIM (Online Mendelian Inheritance in Man): inherited diseases; RefSeq
Brain RNA-Seq [160] An RNA-Seq transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. FusionCancer [161] a database of cancer fusion genes derived from RNA-seq data. Hipposeq a comprehensive RNA-seq database of gene expression in hippocampal principal neurons.
ImmGen database: Open access across all immune system cells; expression data, differential expression, coregulated clusters, regulation: 267: 1059: Jan 2012 Genevestigator: Gene expression search engine based on manually curated, well annotated public and proprietary microarray and RNA-seq datasets: 3228: 232,855: October 2016 Gene Expression ...
The Reference Sequence (RefSeq) database [1] is an open access, annotated and curated collection of publicly available nucleotide sequences (DNA, RNA) and their protein products. RefSeq was introduced in 2000.
Database of long-noncoding RNAs causally implicated in cancer through in vivo, in vitro and other evidence. [15] BIGTranscriptome: High-confidence of coding and noncoding transcriptomes assembled with hundreds of pseudo-stranded and stranded RNA-seq datasets. [16] lncRNAKB
RNA-Seq can also be used to determine exon/intron boundaries and verify or amend previously annotated 5' and 3' gene boundaries. Recent advances in RNA-Seq include single cell sequencing, bulk RNA sequencing, [6] 3' mRNA-sequencing, in situ sequencing of fixed tissue, and native RNA molecule sequencing with single-molecule real-time sequencing. [7]
Gene Expression Omnibus (GEO) is a database for gene expression profiling and RNA methylation profiling managed by the National Center for Biotechnology Information (NCBI). [1] These high-throughput screening genomics data are derived from microarray or RNA-Seq experimental data. [2]
The EMBL Nucleotide Sequence Database (EMBL-Bank) has increased in size from around 600 entries in 1982 to over 2.5×10 8 by December 2012. [16] The EMBL Nucleotide Sequence Database (also known as EMBL-Bank) is the section of the ENA which contains high-level genome assembly details, as well as assembled sequences and their functional annotation.
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