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Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. [7] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. [ 6 ] [ 7 ] Hepatocyte growth factor is secreted by platelets , [ 8 ] and mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial ...
Michalopoulos has researched Hepatocyte Growth Factor (HGF) and its receptor HGFR, also known as MET, and their significance for liver regeneration. He used hepatocyte cultures as bioassays and discovered and identified HGF as a circulating mitogen in peripheral blood. [ 10 ]
The regulatory mechanisms prepare hepatocytes to enter the cell cycle. The proliferation phase involves activation of various growth factors, including two factors that play a major role in liver regeneration, EGFR (epidermal growth factor receptor) and c-Met. During this phase, hepatocytes undergo a series of cell division cycles and expansion ...
9146 15239 Ensembl ENSG00000185359 ENSMUSG00000025793 UniProt O14964 Q99LI8 RefSeq (mRNA) NM_004712 NM_001159328 NM_008244 RefSeq (protein) NP_004703 NP_001152800 NP_032270 Location (UCSC) Chr 17: 81.68 – 81.7 Mb Chr 11: 120.36 – 120.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is ...
Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene. [5] [6] [7]The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing.
Delightfully chewy gnocchi, often made with potatoes, is considered both a type of pasta and a type of dumpling — depending on who you ask. Can it also be a healthier, more nutritious ...
A growth factor receptor is a receptor that binds to a growth factor. [1] Growth factor receptors are the first stop in cells where the signaling cascade for cell differentiation and proliferation begins. Growth factors, which are ligands that bind to the receptor are the initial step to activating the growth factor receptors and tells the cell ...
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