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Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. [7] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
MET is an essential process in embryogenesis to gather mesenchymal-like cells into cohesive structures. [1] Although the mechanism of MET during various organs morphogenesis is quite similar, each process has a unique signaling pathway to induce changes in gene expression profiles.
An example of a vital signal transduction pathway involves the tyrosine kinase receptor, c-met, which is required for the survival and proliferation of migrating myoblasts during myogenesis. A lack of c-met disrupts secondary myogenesis and—as in LBX1—prevents the formation of limb musculature.
The COMT protein is coded by the gene COMT.The gene is associated with allelic variants. The best-studied is Val 158 Met. [15] Others are rs737865 and rs165599 that have been studied, e.g., for association with personality traits, [21] response to antidepressant medications, [22] and psychosis risk associated with Alzheimer's disease. [23]
Several signaling pathways (TGF-β, FGF, EGF, HGF, Wnt/beta-catenin and Notch) and hypoxia may induce EMT. [ 7 ] [ 16 ] [ 17 ] In particular, Ras- MAPK has been shown to activate Snail and Slug. [ 18 ] [ 19 ] [ 20 ] Slug triggers the steps of desmosomal disruption, cell spreading, and partial separation at cell–cell borders, which comprise ...
The signal that starts the MAPK/ERK pathway is the binding of extracellular mitogen to a cell surface receptor.This allows a Ras protein (a Small GTPase) to swap a GDP molecule for a GTP molecule, flipping the "on/off switch" of the pathway.
c-Met stimulates cell scattering, invasion, protection from apoptosis and angiogenesis. [4] c-Met is a receptor tyrosine kinase, [5] which can cause a wide variety of different cancers, such as renal, gastric and small cell lung carcinomas, central nervous system tumours, as well as several sarcomas [6] when its activity is
The met-enkephalin peptide sequence is coded for by the enkephalin gene; the leu-enkephalin peptide sequence is coded for by both the enkephalin gene and the dynorphin gene. [3] The proopiomelanocortin gene ( POMC ) also contains the met-enkephalin sequence on the N-terminus of beta-endorphin, but the endorphin peptide is not processed into ...