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A clinical trial published in the October 1962 American Journal of Obstetrics and Gynecology reported fetal masculinization of the vulvas of 14 of 59 female infants (24%) born to mothers who began high-dose (10–40 mg/day) norethisterone treatment to prevent miscarriage in the first 12 weeks of pregnancy (11 infants had slight clitoral ...
[14] [15] [224] [225] It was first introduced on 18 June 1959 by Upjohn in the United States under the brand name Provera (2.5, 5, and 10 mg tablets) for the treatment of amenorrhea, metrorrhagia, and recurrent miscarriage.
Depot MPA (DMPA) and EC/MPA were developed by Upjohn in the 1960s. [12] [13] DMPA (brand name Depo-Provera) was introduced for use as a progestogen-only injectable contraceptive for the first time outside of the United States in 1969 and was subsequently approved for use in birth control in the United States in 1992.
Miscarriage, also known in medical terms as a spontaneous abortion, is an end to pregnancy resulting in the loss and expulsion of an embryo or fetus from the womb before it can survive independently. [1] [4] Miscarriage before 6 weeks of gestation is defined as biochemical loss by ESHRE.
Medroxyprogesterone acetate (brand names Depo-Provera, Provera, Depo-subQ Provera 104) [4] – 150 mg (intramuscularly) or 104 mg (subcutaneously) every 3 months [3] Norethisterone enanthate (brand names NET EN, Noristerat, Norigest, Doryxas) [ 5 ] – 200 mg (intramuscularly) every 2 months [ 3 ]
Use of progestin-only contraceptives, such as Depo Provera; Change in oral contraception; Overdose of anticoagulant medication or Aspirine abuse; Traumatic causes: Automutilation; Sexual abuse or rape; Related to pregnancy: Implantation bleeding; Ectopic pregnancy (Incomplete) miscarriage; Other causes: Enlarged uterus with menorrhea
"The only way to tell the bleeding, cramping, and pain is from a miscarriage, the abortion pill, or even from an ectopic pregnancy, is to actually do an ultrasound," Dr. William Lile, a pro-life ...
Estradiol valerate/hydroxyprogesterone caproate (EV/OHPC), sold under the brand names Gravibinon and Injectable No. 1 (or Chinese Injectable No. 1) among others, is a combined estrogen and progestogen medication which is used in the treatment of threatened miscarriage and other indications (e.g., as a means of pseudopregnancy) [1] [2] [3] and as a form of combined injectable birth control to ...