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Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's Triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).
Asthma is a common long-term inflammatory disease of the airways of the lungs. [4] ... nasal polyps, sinus disease, and respiratory reactions to aspirin and other ...
Image of aspirin which can be a trigger for asthma in some patients. Aspirin induced asthma, or aspirin-exacerbated respiratory disease, refers to situations where the use of aspirin worsen the asthma conditions. [34] Other non-steroidal anti-inflammatory drugs (NSAIDs) that inhibits the enzyme, cyclooxygenase-1, may also lead to an asthma attack.
Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. [11] For pain or fever, effects typically begin within 30 minutes. [11] Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. [11] One common adverse effect is an upset ...
Max Samter (March 8, 1909 – February 9, 1999) was a German-American immunologist who first extensively studied the triad between asthma, aspirin allergy, and nasal polyps that became known as Samter's triad, now aspirin-exacerbated respiratory disease. [1] Samter was a third generation doctor and obtained medical training in Europe. [2]
Aspirin may also be used to lower the risk of a heart attack or stroke in people who have already had one, O’Mahony says. But that path is not without risk. “This medication can increase the ...
The classification organizes the hypersensitivity reactions to NSAIDs into the following five categories: NSAIDs-exacerbated respiratory disease (NERD) is an acute (immediate to several hours) exacerbation of bronchoconstriction and other symptoms of asthma in individuals with a history of asthma and/or nasal congestion, rhinorrhea or other symptoms of rhinitis and sinusitis in individuals ...
Medications, including aspirin, [14] β-adrenergic antagonists (beta blockers), [15] ibuprofen, and penicillin. [16] Food allergies such as milk, peanuts, and eggs. However, asthma is rarely the only symptom, and not all people with food or other allergies have asthma [17]
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