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While bone loss is a part of aging for many people, certain types of cancer and cancer treatments may lead to bone loss – no matter your age. To better understand bone loss in cancer patients and options for keeping bones healthy, we spoke with Sonali Thosani, M.D. Here’s what she had to say.
Osteoporosis is a potential complication of some cancers and some cancer treatments. People with bone cancer or bone metastasis may develop weak areas in their bones. Cancers such as...
The two largest groups of survivors are women with early-stage breast cancers and men with nonmetastatic prostate cancers (NMPC), and these patients frequently have received cancer treatments that cause particularly high rates of bone loss.
A number of cancer treatments also cause bone loss (Table 1). Estrogens and androgens maintain bone mass and mitigate bone loss.8 Cancer treatments, such as gonadotropin-releasing hormone (GnRH) agonists and chemotherapy-induced ovarian failure (CIOF) in pre-menopausal women, aromatase inhibitors (AIs) in post-
Both cancer and various treatments, such as high-dose steroids, ablative cytotoxic chemotherapy, and radiation, negatively affect bone health and place survivors of cancer at risk of osteoporosis and osteopenia.
Thinning bone can lead to osteoporosis, increasing the risk of fractures and bone pain. The researchers also showed that two investigational drugs could block molecular signals from senescent cells that disrupt bone remodeling in mice.
Cancer and its treatment can have profound effects on bone health. Clinicians treating cancer patients need to be aware of the multidisciplinary treatments available to reduce skeletal morbidity from metastatic disease and minimise cancer treatment-induced damage to the normal skeleton.