Search results
Results from the WOW.Com Content Network
Fluconazole is an antifungal medication used for a number of fungal infections. [5] This includes candidiasis , blastomycosis , coccidioidomycosis , cryptococcosis , histoplasmosis , dermatophytosis , and tinea versicolor . [ 5 ]
Antifungal medications that target ergosterol synthesis are selectively toxic to the fungi, hence, killing and stopping the growth of fungi in the body. When ergosterol is damaged, it causes the contents inside the fungal cells to leak out, preventing further reproduction of fungal cells. Lastly, antifungal agents contribute to fungal cell death.
It can proliferate well at 37 °C (99 °F), a temperature similar to the human body's internal temperature. When it is incubated at 37 °C (99 °F), reactive oxygen species accumulate and damage its DNA, which causes mutations that lead to the development of resistance to amphotericin-B .
Some fungi (e.g. Candida krusei and fluconazole) exhibit intrinsic resistance to certain antifungal drugs or classes, whereas some species develop antifungal resistance to external pressures. Antifungal resistance is a One Health concern, driven by multiple extrinsic factors, including extensive fungicidal use, overuse of clinical antifungals ...
In most cases, the diagnosis is established based on response to therapy. Patients in whom esophageal candidiasis is suspected should receive a brief course of antifungal therapy with fluconazole. If the infection resolves after treatment with fluconazole, then the diagnosis of esophageal candidiasis is made and no further investigation is needed.
Fluconazole is the preferred medication for coccidioidal meningitis, due to its penetration into CSF. [3] Intrathecal or intraventricular amphotericin B therapy is used if infection persists after fluconazole treatment. [31] Itraconazole is used for cases that involve treatment of infected person's bones and joints.
Get breaking news and the latest headlines on business, entertainment, politics, world news, tech, sports, videos and much more from AOL
Ketoconazole has activity against many kinds of fungi that may cause human disease, such as Candida, Histoplasma, Coccidioides, and Blastomyces (although it is not active against Aspergillus), chromomycosis and paracoccidioidomycosis. [23] [13] First made in 1977, [20] ketoconazole was the first orally-active azole antifungal medication. [23]