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Sarcoidosis is characterized by the formation of non-necrotizing ("non-caseating") granulomas in various organs and tissues. [95] Giant cells, specifically Langhans giant cells, are often seen in sarcoidosis. [96] Schaumann bodies seen in sarcoidosis are calcium and protein inclusions inside of giant cells as part of a granuloma. [97]
Granuloma; Picture of a granuloma (without necrosis) as seen through a microscope on a glass slide: The tissue on the slide is stained with two standard dyes (hematoxylin: blue, eosin: pink) to make it visible. The granuloma in this picture was found in a lymph node of a patient with a Mycobacterium avium infection. Specialty: Pathology
The acute form can be characterized by poorly formed noncaseating interstitial granulomas and mononuclear cell infiltration in a peribronchial distribution with prominent giant cells. [1] The subacute, or intermittent, form produces more well-formed noncaseating granulomas, bronchiolitis with or without organizing pneumonia , and interstitial ...
It has been defined histologically as the presence of (non-caseating) granuloma and lymphoproliferation in the lung. [1] However, as GLILD is often associated with other auto-immune features such as splenomegaly , adenopathy and cytopenias , a definition based on abnormalities on lung imaging (CT scan) together with evidence of granulomatous ...
Caseous necrosis in the kidney. In caseous necrosis no histological architecture is preserved (unlike with coagulative necrosis). [5] [6] On microscopic examination with H&E staining, the area is acellular, characterised by amorphous, roughly granular eosinophilic debris of now dead cells, [6] also containing interspearsed haematoxyphilic remnants of cell nucleus contents. [5]
It usually includes the formation of a foreign body granuloma. [2] Tissue encapsulation of an implant is an example, as is inflammation around a splinter . [ 3 ] Foreign body granuloma formation consists of protein adsorption , macrophages , multinucleated foreign body giant cells (macrophage fusion), fibroblasts , and angiogenesis .
Chronic exposure to beryllium can be histologically characterised by non-caseating granulomas—structures formed in certain infectious and toxin-mediated diseases in which tissue resident macrophages build a wall around the threat, thus nullifying it. Because of this, beryllium associated granulomas are occasionally responsive to steroids and ...
Granulomatous mastitis can be divided into idiopathic granulomatous mastitis (also known as granular lobular mastitis [1]) and granulomatous mastitis occurring as a rare secondary complication of a great variety of other conditions such as tuberculosis and other infections, sarcoidosis and granulomatosis with polyangiitis.