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Whereas the biological half-life of estradiol given by intravenous injection is about 0.5 to 2 hours, the biological half-life of oral estradiol has a range of 13 to 20 hours due to the large and long-lasting pool of estrogen conjugates that is formed during first-pass metabolism and that serves to continuously replenish circulating estradiol ...
Estradiol is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the biological target of estrogens like endogenous estradiol. [11] Due to its estrogenic activity, estradiol has antigonadotropic effects and can inhibit fertility and suppress sex hormone production in both women and men.
The levonorgestrel implant is a type of long-acting reversible birth control. [5] It primarily works by stopping ovulation and by thickening the mucus around the cervix. [4] A levonorgestrel-releasing implant was approved for medical use in 1983 in Finland and in the United States in 1990. [1]
The transition lasts until someone officially enters menopause—which is exactly one year after their last period, usually around age 51. ... In some cases, Greves adds, vaginal estrogen works ...
Fat tissue can produce excess estrogen, so those with a higher body fat percentage may have high estrogen levels, says Dr. Guichard. There's an inverse relationship here, too: Higher estrogen ...
The female body has estrogen receptors almost everywhere, Garrison explains, so, as estrogen levels begin to fluctuate during perimenopause, then drop after menopause, the impacts can be far-reaching.
Menstrual cycle The menstrual cycle is a series of natural changes in hormone production and the structures of the uterus and ovaries of the female reproductive system that makes pregnancy possible. The ovarian cycle controls the production and release of eggs and the cyclic release of estrogen and progesterone. The uterine cycle governs the preparation and maintenance of the lining of the ...
The use of high-dose estrogen therapy in breast cancer has mostly been superseded by antiestrogen therapy due to the improved safety profile of the latter. [17] High-dose estrogen therapy was the standard of care for the palliative treatment of breast cancer in women up to the late 1970s or early 1980s. [18
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