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In Graves' disease, treatment with antithyroid medications must be given for six months to two years, in order to be effective. Even then, upon cessation of the drugs, the hyperthyroid state may recur. Side effects of the antithyroid medications include a potentially fatal reduction in the level of white blood cells.
Thiamazole is a drug used to treat hyperthyroidism such as in Graves' disease, a condition that occurs when the thyroid gland begins to produce an excess of thyroid hormone. The drug may also be taken before thyroid surgery to lower thyroid hormone levels and minimize the effects of thyroid manipulation.
Amiodarone, an antiarrhythmic drug, is structurally similar to thyroxine and may cause either under-or overactivity of the thyroid. [citation needed] Postpartum thyroiditis (PPT) occurs in about 7% of women during the year after they give birth. PPT typically has several phases, the first of which is hyperthyroidism.
Antithyroid drugs (propylthiouracil or methimazole) are used to reduce the synthesis and release of thyroid hormone. Propylthiouracil is preferred over methimazole due to its additional effects on reducing peripheral conversion of T4 to T3, [5] however both are commonly used.
Thioamides or anti-thyroid drugs are also a class of drugs that are used to control thyrotoxicosis. Thioamides have been incorporated into peptides as isosteres for the amide bond. [ 10 ] Peptide modifications are analogues of the native peptide, which can reveal the structure-activity relationship ( SAR ).
Antithyroid drugs (8 P) H. Hormones of the hypothalamus-pituitary-thyroid axis (8 P) Hormones of the thyroid gland (11 P) I. Iodinated tyrosine derivatives (14 P) T.
Pages in category "Antithyroid drugs" The following 8 pages are in this category, out of 8 total. This list may not reflect recent changes. A. Amphenone B;
Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin , hence reducing the production of the thyroid hormones T 3 and T 4 ( thyroxine ).