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S.M., sometimes referred to as SM-046, is an American woman with a peculiar type of brain damage that physiologically reduces her ability to feel fear.First described by scientists in 1994, [1] she has had exclusive and complete bilateral amygdala destruction since late childhood as a consequence of Urbach–Wiethe disease.
Urbach–Wiethe disease is inherited in an autosomal recessive manner. Urbach–Wiethe disease is a very rare recessive genetic disorder, with approximately 400 reported cases since its discovery. [1] [2] [3] It was first officially reported in 1929 by Erich Urbach and Camillo Wiethe, [4] [5] although cases may be recognized dating back as ...
Klüver–Bucy syndrome is a syndrome resulting from lesions of the medial temporal lobe, particularly Brodmann area 38, [1] causing compulsive eating, hypersexuality, a compulsive need to insert inappropriate objects in the mouth (hyperorality), visual agnosia, and docility.
The other day a colleague sent me a text to cancel a meeting. “I’ve been so sick for the past several days,” she began. “I’ll need to reschedule.” I wasn’t sure whether she meant she ...
And yet, according to research, that fear—while totally fair—isn’t helpful. Related: This Daily Snack May Cut Your Dementia Risk by 12%, According to Study Worrying About Cognitive Decline ...
Urbach-Wiethe disease (UWD) is a rare genetic disorder characterized by early damage to the basolateral amygdala. Perhaps more than 50% of the world's population of UWD live in South Africa, and together with his doctoral student, Helena Thornton , Stein initiated work on the neuropsychology of UWD.
There are cases of human patients with focal bilateral amygdala lesions due to the rare genetic condition Urbach-Wiethe disease. [86] [87] Such patients fail to exhibit fear-related behaviors, leading one, S.M., to be dubbed the "woman with no fear". This finding reinforces the conclusion that the amygdala "plays a pivotal role in triggering a ...
The collections of bacteria in the gut may play a role in the regulation of stress responses, an animal study suggests. Image credit: Justin Lewis/Getty Images.