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Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol.It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
Unlike the other twelve vitamins, vitamin D is only conditionally essential - in a preindustrial society people had adequate exposure to sunlight and the vitamin was a hormone, as the primary natural source of vitamin D was the synthesis of cholecalciferol in the lower layers of the skin’s epidermis, triggered by a photochemical reaction with ...
The vitamin D receptor (VDR also known as the calcitriol receptor) is a member of the nuclear receptor family of transcription factors. [5] Calcitriol (the active form of vitamin D , 1,25-(OH) 2 vitamin D 3 ) binds to VDR, which then forms a heterodimer with the retinoid-X receptor .
Parathyroid hormone: PTH Peptide: parathyroid gland: parathyroid chief cell: PTH receptor → cAMP: increase blood Ca 2+: indirectly stimulate osteoclasts; Ca 2+ reabsorption in kidney; activate vitamin D (Slightly) decrease blood phosphate: (decreased reuptake in kidney but increased uptake from bones; activate vitamin D) 52
This latter form of vitamin D is the active hormone which stimulates calcium uptake from the intestine. [22] Via the kidney, PTH enhances the absorption of calcium in the intestine by increasing the production of activated vitamin D. Vitamin D activation occurs in the kidney.
Menopausal hormone therapy. Often used to treat menopausal symptoms, menopausal hormone therapy may also help prevent bone loss. ... Vitamin D helps your body absorb calcium from the food you eat ...
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