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Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene. [ 5 ] [ 6 ] DBP is genetically the oldest member of the albuminoid family and appeared early in the evolution of vertebrates.
In molecular biology, Vitamin D binding protein domain III protein domain is predominantly found in Vitamin D binding proteins (DBP). Vitamin D-binding protein (DBP)(also referred to as Gc-globulin) is synthesized primarily in the liver. This entry outlines the domain III of DBP. Domain III (amino acid 379–458) is G-actin binding region ...
The VDR is widely distributed in tissues, and is not restricted to those tissues considered the classic targets of vitamin D. The VDR upon binding to 1,25(OH) 2 D heterodimerizes with other nuclear hormone receptors, in particular the family of retinoid X receptors. This VDR/RXR heterodimer complex binds to the specific VDRE in the promoters of ...
Metabolites produced from vitamin D 2 tend to bind less well to the vitamin D-binding protein. [3] Vitamin D 3 can alternatively be hydroxylated to calcifediol by sterol 27-hydroxylase, an enzyme coded for by gene CYP27A1, but vitamin D 2 cannot. [3] Ergocalciferol can be directly hydroxylated at position 24 by the enzyme coded for by CYP27A1. [3]
A binding protein is any protein that acts as an agent to bind two or more molecules together. Examples include: ... Vitamin D-binding protein; Syntaxin binding ...
GcMAF (or Gc protein-derived macrophage activating factor) is a protein produced by modification of vitamin D-binding protein. [1] It has been falsely promoted as a treatment for various medical conditions, but claims of its benefits are not supported by evidence.
280662 Ensembl ENSG00000079557 ENSMUSG00000029369 UniProt P43652 O89020 RefSeq (mRNA) NM_001133 NM_145146 RefSeq (protein) NP_001124 NP_660128 Location (UCSC) Chr 4: 73.48 – 73.5 Mb Chr 5: 90.67 – 90.7 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Afamin is a protein that in humans is encoded by the AFM gene. Function This gene is a member of the albumin gene family, which ...
Calbindins are three different calcium-binding proteins: calbindin, calretinin and S100G. They were originally described as vitamin D-dependent calcium-binding proteins in the intestine and kidney of chicks and mammals. They are now classified in different subfamilies as they differ in the number of Ca 2+ binding EF hands.