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Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene. [ 5 ] [ 6 ] DBP is genetically the oldest member of the albuminoid family and appeared early in the evolution of vertebrates.
Vitamin D response element (VDRE) is a type of DNA sequence that is found in the promoter region of vitamin D regulated genes. This sequence binds the vitamin D receptor (VDR), when complexed with calcitriol (1,25(OH) 2 D), the active form of vitamin D, and so regulates the expression of many genes.
The VDR gene encodes the nuclear hormone receptor for vitamin D. The most potent natural agonist is calcitriol (1,25-dihydroxycholecalciferol) and the vitamin D 2 homologue ercalcitriol, 1-alpha,25-dihydroergocalciferol) is also a strong activator. Other forms of vitamin D bind with lower affinity, as does the secondary bile acid lithocholic ...
In molecular biology, Vitamin D binding protein domain III protein domain is predominantly found in Vitamin D binding proteins (DBP). Vitamin D-binding protein (DBP)(also referred to as Gc-globulin) is synthesized primarily in the liver. This entry outlines the domain III of DBP. Domain III (amino acid 379–458) is G-actin binding region ...
Metabolites produced from vitamin D 2 tend to bind less well to the vitamin D-binding protein. [ 3 ] Vitamin D 3 can alternatively be hydroxylated to calcifediol by sterol 27-hydroxylase (CYP27A1), but vitamin D 2 cannot.
A number of blood transport proteins are evolutionarily related in the albumin family, including serum albumin, alpha-fetoprotein, vitamin D-binding protein and afamin. [3] [4] [5] This family is only found in vertebrates. [6] Albumins in a less strict sense can mean other proteins that coagulate under certain conditions.
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Transcription of the CYP24A1 gene is markedly inducible by 1,25-(OH) 2 D 3 binding to the vitamin D receptor. [6] The gene has a strong, positive vitamin D response element in the promoter. Through regulation of CYP24A1 expression, a negative feedback control system is created to limit the effects of 1,25-(OH) 2 D 3. [6] PTH and FGF23 also ...