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There is a risk of metastasis starting more than 10 years [citation needed] after diagnosable appearance of squamous-cell carcinoma, but the risk is low, [specify] though much [specify] higher than with basal-cell carcinoma. Squamous-cell cancers of the lip and ears have high rates of local recurrence and distant metastasis. [27]
Kaposi's sarcoma (KS) is a type of cancer that can form masses on the skin, in lymph nodes, in the mouth, or in other organs. [ 4 ] [ 6 ] The skin lesions are usually painless, purple and may be flat or raised.
All squamous cell carcinoma lesions are thought to begin via the repeated, uncontrolled division of cancer stem cells of epithelial lineage or characteristics. Accumulation of these cancer cells causes a microscopic focus of abnormal cells that are, at least initially, locally confined within the specific tissue in which the progenitor cell resided.
HSV1716 is a first generation oncolytic virus developed by the Glasgow Institute of Virology, and subsequently by Virttu Biologics (formerly Crusade Laboratories, a spin-out from The Institute of Virology), to selectively destroy cancer cells. The virus has the trade name SEPREHVIR. It is based on the herpes simplex virus (HSV-1).
The most common reason to use cytological examination in malignant tumoral diseases is to distinguish basal cell carcinoma from other tumors, such as squamous cell carcinoma and melanoma. Tzanck smear test is 97% sensitivity and 86% specificity for the diagnosis of basal cell carcinoma. Squamous cell carcinoma: Cytologic atypia of keratinocytes
Squamous-cell carcinoma (SCC), also known as epidermoid carcinoma, comprises a number of different types of cancer that begin in squamous cells. [1] These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts .
Severe dysplasia / carcinoma in situ HPV-negative lesion with atypical keratinocytes in the basal cell layer WHO 2003 [3] Vulvar intraepithelial neoplasia (VIN) 1: VIN 2: VIN 3: VIN 3 WHO 2014 and ISSVD 2015 [3] Low-grade squamous intraepithelial lesion (LSIL) High-grade squamous intraepithelial lesion (HSIL) Intraepithelial neoplasia ...
The herpes simplex virus type 1 (HSV-1) mutant 1716 lacks both copies of the ICP34.5 gene, and as a result is no longer able to replicate in terminally differentiated and non-dividing cells but will infect and cause lysis very efficiently in cancer cells, and this has proved to be an effective tumour-targeting strategy.