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2. RALES (trial) - Wikipedia

   en.wikipedia.org/wiki/RALES_(trial)

   The RALES trial established spironolactone as a vital component of therapy for patients with severe heart failure, demonstrating significant reductions in mortality and hospitalization and improvements in symptoms. The trial's findings have been instrumental in shaping current heart failure treatment guidelines and improving patient outcomes.

3. Management of heart failure - Wikipedia

   en.wikipedia.org/wiki/Management_of_heart_failure

   Sleep apnea is an under-recognized risk factor for heart failure. Uncontrolled sleep apnea may increase the risk of heart failure by up to 140%. [4] Weight reduction – through physical activity and dietary modification, as obesity is a risk factor for heart failure and left ventricular hypertrophy. Effective weight management has been shown ...

4. Mineralocorticoid receptor antagonist - Wikipedia

   en.wikipedia.org/wiki/Mineralocorticoid_receptor...

   This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure. Spironolactone, the first member of the class, is also used in the management of hyperaldosteronism (including Conn's syndrome) and female hirsutism (due to additional antiandrogen actions).

5. Heart failure - Wikipedia

   en.wikipedia.org/wiki/Heart_failure

   Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome caused by an impairment in the heart's ability to fill with and pump blood.. Although symptoms vary based on which side of the heart is affected, HF typically presents with shortness of breath, excessive fatigue, and bilateral leg swelling. [3]

6. Potassium-sparing diuretic - Wikipedia

   en.wikipedia.org/wiki/Potassium-sparing_diuretic

   They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. [3] The steroidal aldosterone antagonists can also be used for treatment of primary hyperaldosteronism. Spironolactone, a steroidal aldosterone antagonist, is also used in management of female hirsutism and acne from PCOS or other ...

7. Spironolactone - Wikipedia

   en.wikipedia.org/wiki/Spironolactone

   Spironolactone, sold under the brand name Aldactone among others, is a diuretic medication primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. [4] It is also used in the treatment of high blood pressure , and low blood potassium that does not improve with supplementation , early puberty in boys, acne ...

8. The best Kohl's Cyber Monday deals to shop before the sale ...

   www.aol.com/lifestyle/the-best-kohls-cyber...

   It's your last chance to scoop up some Cyber Monday savings at Kohl's. Shop our favorite deals before time runs out.

9. Cardiovascular agents - Wikipedia

   en.wikipedia.org/wiki/Cardiovascular_agents

   Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]