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2. RALES (trial) - Wikipedia

   en.wikipedia.org/wiki/RALES_(trial)

   The RALES trial established spironolactone as a vital component of therapy for patients with severe heart failure, demonstrating significant reductions in mortality and hospitalization and improvements in symptoms. The trial's findings have been instrumental in shaping current heart failure treatment guidelines and improving patient outcomes.

3. Heart failure - Wikipedia

   en.wikipedia.org/wiki/Heart_failure

   Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome caused by an impairment in the heart's ability to fill with and pump blood.. Although symptoms vary based on which side of the heart is affected, HF typically presents with shortness of breath, excessive fatigue, and bilateral leg swelling. [3]

4. Mineralocorticoid receptor antagonist - Wikipedia

   en.wikipedia.org/wiki/Mineralocorticoid_receptor...

   However, spironolactone is metabolized to three active metabolites, which give it prolonged activity (13.8 – 16. 5 hours). Spironolactone has a long half-life and is excreted 47-51% through kidneys. Patients with chronic kidney disease therefore require close monitoring when taking the drug. Spironolactone is also eliminated through feces (35-41%

5. Mediterranean diet can help lower heart failure risk ... - AOL

   www.aol.com/mediterranean-diet-help-lower-heart...

   Mediterranean diet linked to lower heart failure risk in women. This review results was conducted by a team of experts from the University of Palermo, the Kore University of Enna, ...

6. Potassium-sparing diuretic - Wikipedia

   en.wikipedia.org/wiki/Potassium-sparing_diuretic

   They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. [3] The steroidal aldosterone antagonists can also be used for treatment of primary hyperaldosteronism. Spironolactone, a steroidal aldosterone antagonist, is also used in management of female hirsutism and acne from PCOS or other ...

7. Could Spironolactone Help Women With Hair Thinning, Facial ...

   www.aol.com/could-spironolactone-help-women-hair...

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8. Spironolactone - Wikipedia

   en.wikipedia.org/wiki/Spironolactone

   Spironolactone, sold under the brand name Aldactone among others, is a diuretic medication primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. [4] It is also used in the treatment of high blood pressure , and low blood potassium that does not improve with supplementation , early puberty in boys, acne ...

9. Cardiovascular agents - Wikipedia

   en.wikipedia.org/wiki/Cardiovascular_agents

   Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]