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Antipsychotics have been reported to cause hyponatremia in a review of medical articles from 1946 to 2016. [25] Available evidence suggests that all classes of psychotropics, i.e., antidepressants, antipsychotics, mood stabilizers, and sedative/hypnotics can lead to hyponatremia. Age is a significant factor for drug induced hyponatremia.
More severe hyponatremia (levels less than 120 mEq/L), particularly if it develops rapidly (defined as occurring over less than 48 hours), can cause confusion, seizures and even lead to death ...
Psychomotor agitation is typically found in various mental disorders, especially in psychotic and mood disorders. It can be a result of drug intoxication or withdrawal. It can also be caused by severe hyponatremia. People with existing psychiatric disorders and men under the age of 40 are at a higher risk of developing psychomotor agitation. [2]
The causes of hyponatremia are typically classified by a person's body fluid status into low volume, normal volume, or high volume. [35] Low volume hyponatremia can occur from diarrhea, vomiting, diuretics, and sweating. [35] Normal volume hyponatremia is divided into cases with dilute urine and concentrated urine. [35]
Severity of symptoms is directly correlated with severity of hyponatremia and rapidness of onset. [3] General symptoms include loss of appetite, nausea, vomiting, confusion, agitation, and weakness. [ 14 ] [ 3 ] More concerning symptoms involve the central nervous system and include seizures, coma, and death due to brain herniation .
Like their adult counterparts, children and adolescents suffering from depression are at an increased risk of attempting or committing suicide. [15] Suicide is the fourth leading cause of death among 15- to 19-year-olds. [16]
Neurocognitive symptoms can vary from agitation, issues with concentration, and depression, to delirium and coma. [ 7 ] During an adrenal crisis laboratory testing may show low sodium ( hyponatremia ), high potassium ( hyperkalemia ), high lymphocyte count ( lymphocytosis ), high eosinophils ( eosinophilia ), low blood sugar ( hypoglycemia ...
In severe or acute hypoosmolar hyponatremia, swelling of brain cells causes various neurological abnormalities, which in severe or acute cases can result in convulsions, coma, and death. The symptoms of chronic syndrome of inappropriate antidiuresis are more vague, and may include cognitive impairment , gait abnormalities , or osteoporosis .
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