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Ciprofloxacin is weakly bound to serum proteins (20–40%). It is an inhibitor of the drug-metabolizing enzyme cytochrome P450 1A2, which leads to the potential for clinically important drug interactions with drugs metabolized by that enzyme. [5] Ciprofloxacin is about 70% available when administered orally. [3]
Common side effects include gastrointestinal effects such as nausea, vomiting, and diarrhea, as well as headache and insomnia. Postmarketing surveillance has revealed a variety of relatively rare but serious adverse effects associated with all members of the fluoroquinolone antibacterial class.
[9] [11] This medication is typically taken orally and has minimal systemic absorption, reducing potential side effects. [12] Common adverse reactions associated with nitrofurantoin include brown urine discoloration, nausea, vomiting, loss of appetite, rash, and peripheral neuropathy. [13]
Possible side effects [4] Mechanism of action Aminoglycosides; Amikacin: Amikin: Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against aerobic bacteria (not obligate/facultative anaerobes) and tularemia. All aminoglycosides are ineffective when taken orally as ...
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Therefore, potential risks of side effects and effectiveness depend on the type of antibiotic administered. [ 63 ] Antibiotics such as metronidazole , tinidazole , cephamandole , latamoxef , cefoperazone , cefmenoxime , and furazolidone , cause a disulfiram -like chemical reaction with alcohol by inhibiting its breakdown by acetaldehyde ...
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A 2018 systematic review recommended the use of norfloxacin as it has the lowest rate of side effects with a comparable efficacy to commonly used antibiotics. [ 29 ] In people who do not require hospitalization and live in an area where there is a low prevalence of antibiotic-resistant bacteria, a fluoroquinolone by mouth such as ciprofloxacin ...
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