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A second MAOA VNTR promoter, P2, influences epigenetic methylation and interacts with having experienced child abuse to influence antisocial personality disorder symptoms, only in women. [58] A study of 34 non-smoking men found that methylation of the gene may alter its expression in the brain.
Brunner syndrome is a rare genetic disorder associated with a mutation in the MAOA gene. It is characterized by lower than average IQ (typically about 85), problematic impulsive behavior (such as pyromania, hypersexuality and violence), sleep disorders and mood swings. [1] [2] It was identified in fourteen males from one family in 1993.
[82] [83] Even when environmental interactions (e.g., emotional abuse) are taken out of the equation, a small association between MAOA-L and aggressive and antisocial behavior remains. [84] The gene that encodes for the serotonin transporter (SLC6A4), a gene that is heavily researched for its associations with other mental disorders, is another ...
Rare mutations in the gene are associated with Brunner syndrome. [medical citation needed] A study based on the Dunedin cohort concluded that maltreated children with a low-activity polymorphism in the promoter region of the MAO-A gene were more likely to develop antisocial conduct disorders than maltreated children with the high-activity ...
A functional polymorphism in the monoamine oxidase A (MAOA) gene promoter can moderate the association between early life trauma and increased risk for violence and antisocial behavior. Low MAOA activity is a significant risk factor for aggressive and antisocial behavior in adults who report victimization as children.
Terrie Edith Moffitt MBE FBA (born March 9, 1955) is an American-British clinical psychologist who is best known for her pioneering research on the development of antisocial behavior and for her collaboration with colleague and partner Avshalom Caspi in research on gene-environment interactions in mental disorders.
The human genetics related to aggression have been studied and the main genes have been identified. The DAT1 and DRD2 genes are heavily related to the genetics of aggression. [17] [18] The DAT1 gene plays a role for its heavy relation to regulation of neurotransmission. The DRD2 Gene results in humans finding seemingly rewarding paths such as ...
[2] [5] He has also researched the link between parenting behavior and child intelligence, [6] as well as the potential for genetic factors to contribute to academic achievement in children. [7] His research has also found a link between a rare form of the MAOA gene (known as the "warrior gene") and violent behavior and weapon use among boys. [8]